Natural Remedies For Inflammation

With the fanfare of a holiday parade, drug companies a few years ago unveiled two new Cox-2 inhibitor drugs-Celebrex and Vioxx-to treat arthritis, inflammation, premenstrual syndrome, and potentially even cancer. All the hoopla paid off. Since then, doctors have written more than seven million prescriptions for these “super aspirin” drugs, earning hundreds of million dollars for their makers.

Cox-2 is short for cyclooxygenase-2, one of the key enzymes that helps the body produce inflammatory hormone-like compounds called prostaglandins and cytokines. Cox-2 is essential-without it, we wouldn’t be able to fight infections or heal injuries. But when the body overproduces Cox-2, the result is chronic inflammation and pain.

The intensive marketing and advertising of Cox-2 inhibitors obscured why many people overproduce the enzyme. Too much Cox-2 appears to result from imbalances and deficiencies of certain nutrients. Rather than correct these underlying dietary problems, pharmaceutical Cox-2 inhibitors only mask the most visible symptoms. Relatively minor dietary changes, plus some vitamin and herbal supplements, correct the underlying problems.

Problems with Cox-2 Inhibitor Drugs

For years, people have used nonsteroidal antiinflammatory drugs (NSAIDS), such as ibuprofen, to treat the inflammation and pain associated with rheumatoid arthritis and osteoarthritis. NSAIDS ease inflammation by inhibiting the activity of both Cox-2 and Cox-1, the latter an enzyme that helps maintain homeostasis (biological equilibrium) protect the stomach lining. Because stomach ulcers occur in about 25 percent of NSAID users, pharmaceutical companies worked to develop NSAIDS that blocked only the activity of Cox-2. The idea was that a selective Cox-2 inhibitor would reduce inflammation but not irritate the stomach.

The motivation was profiting from a potentially huge market. An estimated 40 million Americans suffer from some form of arthritis. In a typical year, physicians write about 60 million prescriptions for NSAIDS-to say nothing of their over-the-counter sales. However, each year some half-million people develop complications from NSAIDS, with an estimated 80,000 people requiring hospitalization and 8,000 dying.

Though touted for their relative safety, Cox-2 inhibitors may be far more hazardous than originally believed. While gastrointestinal problems with Cox-2 inhibitors occur less frequently, they can be severe. Just four months after the FDA approved Celebrex, 10 deaths from the drug were reported. One study has even suggested that Cox-2 is important to the gut and healing ulcers, suggesting that pharmaceutical tampering with the enzyme may not be wise.

The Double-Edged Sword of Inflammation

Nutrients supply the most basic building blocks of the body’s powerful inflammatory compounds. The “parent” nutrient is linoleic acid, found in many foods but especially concentrated in vegetable oils (e.g., corn, soy, and safflower oils). The body converts linoleic acid to the omega-6 family of fatty acids, including arachidonic acid. Cox-2 plays a critical role in converting arachidonic acid to the hormone-like prostaglandin E2 (PGE2) and to the cytokines interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor alpha (TNFa), all of which promote inflammation.

According to Robert F. Grimble, Ph.D., of the University of Southampton, England, once an infection or injury stimulates production of IL-1 and TNFa, these two proinflammatory compounds can further stimulate each other, as well as IL-6. In addition, IL-1 and TNF a trigger the production of free radicals, which encourage the production of more proinflammatory cytokines. The proinflammatory reaction essentially feeds on itself, setting the stage for chronic inflammation.

Ideally, the body balances these compounds with a group of antiinflammatory compounds that originate with alpha-linolenic acid, found in cold-water fish, leafy green vegetables, and flaxseed. The body converts alpha-linolenic acid to the omega-3 family of fatty acids, which include eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Preformed EPA and DHA are also found in cold-water fish.

Much of the problem with inflammatory disorders actually stems from a lopsided imbalance in dietary intake of the omega-6 and omega-3 fatty acids-and the consequential cascade in proinflammatory activity. Artemis Simopolous, M.D., director of the Center for Genetics, Nutrition and Health in Washington, D.C., has shown that people historically consumed roughly equal amounts of the proinflammatory omega-6 fatty acids and the antiinflammatory omega-3 fatty acids.

However, over the past 30 years or so, Americans have replaced much of their dietary saturated fat (a bystander, so far as inflammation is concerned) with omega-6 fatty acids. Simopoulos estimates that people are now eating 20 times more omega-6s than omega-3s. From a biochemical standpoint, this sets the stage for powerful and chronic proinflammatory reactions.

Indeed, inflammation plays a role in many diseases, including arthritis, gingivitis and most of “-itis” diseases. Recent research has pointed to the role of inflammation in heart disease, stroke, and even Alzheimer’s disease. In addition, Bruce N. Ames, Ph.D., of the University of California, Berkeley, has estimated that chronic inflammation and infection cause about one-third of all cancers.

This relationship between diet, inflammation, and cancer was recently demonstrated by researchers at the American Health Foundation, Valhalla, New York. In animal experiments, they noted that corn oil (rich in omega-6) increased Cox-2 activity, whereas fish oil (rich in omega-3) blunted Cox-2 activity. The researchers also showed that the omega-6 fatty acids could promote the growth of colon cancer, whereas the omega-3 fatty acids prevented cancer.

In addition to a diet containing too many omega-6 fatty acids, a shortage of nutritional antioxidants, such as vitamin E, also contributes to chronic inflammation. The proinflammatory cytokines, IL-1 and TNFa, trigger the release of free radicals. A diet rich in antioxidants-found chiefly in vegetables and fruit-can help neutralize these free radicals. But relatively few people-9 to 34 percent, according to different researchers-eat the recommended five daily servings of vegetables and fruit. Between an excess omega-6 fatty acids and a lack of omega-3 fatty acids, and inadequate intake of antioxidants, the body’s proinflammatory reaction goes out of control, leading to chronic inflammation and pain.

Quenching the Fires of Inflammation

The simplest and most biochemically sound way of turning down the body’s proinflammatory prostaglandins and cytokines is by restoring a balance between pro- and antiinflammatory foods. From a dietary standpoint, this means switching from vegetable oils to extra-virgin olive oil (high in antiinflammatory omega-9 fatty acids). It also means avoiding most processed (boxed, canned, or frozen) foods, because their makers frequently add omega-6 fatty acids. By eating simple unprocessed foods-such as baked chicken, a salad, and steamed vegetables-it becomes easier to consume a more balanced ratio of omega-6 and omega-3 fatty acids.

However, if you’re like most people, you’ve been eating a diet high in omega-6 fatty acids and low in antioxidants for years. Simply restoring a balance is not enough to quickly offset accumulated damage, because the fatty acid composition of the body’s cells reflects their dietary ratios. It’s imperative to increase consumption of antiinflammatory fatty acids and antioxidants.

These are the supplements to emphasize:

  • Omega-3 essential fatty acids
  • Found in fish oils, EPA and DHA are essential building blocks for the body’s antiinflammatory prostaglandins (e.g., prostaglandin E1) and for turning off Cox-2 and the body’s proinflammatory cytokines (IL-1, IL-6, and TNFa). In addition, omega-3 fatty acids block the activity of an enzyme that breaks down joint cartilage. Daily dosage: 3 or more grams.

  • Vitamin E
  • Although Cox-2 and prostaglandin E2 levels rise with age, animal studies have shown that vitamin E supplements reverse the increase in Cox-2 and prostaglandin E2. Vitamin E also turns off nuclear factor-kB (NF-kB) and activator protein-1 (AP-1), compounds that turn on inflammatory genes. One recent study found that arthritics taking supplements of natural vitamin E (600 mg twice daily) for 12 weeks had their pain reduced by about half. Daily dosage: 400-800 IU.

  • Polyphenols and Flavonoids
  • Researchers at Case Western Reserve University, Cleveland, recently reported that the antioxidant polyphenols in green tea had antiinflammatory properties by inhibiting Cox-2 and TNFa. Genistein inhibits prostaglandin E2 and Cox-2, and quercetin inhibits the activity of inflammation-promoting “adhesion” molecules. It’s likely that Pycnogenol, grape seed extract, and other flavonoids work through similar mechanisms. Daily dosage: 25-500 mg.

  • Silymarin
  • A cell-culture study found that silymarin, the antioxidant extract of milk thistle, inhibited Cox-2 formation. This role of silymarin may partly explain why earlier cell-culture studies found it to inhibit the growth of prostate, breast, and skin cancers. Daily dosage: 100-200 mg.

  • Rosemary
  • This common kitchen herb is rich in ursolic acid and many of its derivatives. In laboratory experiments, Swedish researchers found that the ursolic acid extract of rosemary was a potent inhibitor of Cox-2 activity. Daily dosage: 100 mg.

  • Cat’s Claw
  • Known as una de gato and Uncaria tomentosa, this Peruvian herb has a long history as a remedy for inflammatory arthritis. Recent cell-culture and animal experiments at the Albany Medical College, New York, found that cat’s claw inhibited inflammation by blocking the activity of NF-kB. Daily dosage: Because products vary, follow label directions.

The take home message in all this is relatively simple: pharmaceutical drugs, while providing rapid relief of symptoms, do not correct the underlying cause of chronic inflammation. The cause is frequently a diet that’s either unbalanced or lacking in key nutrients. No drug can correct a nutritional deficiency or imbalance. Only nutrients can do that.

  • Betsy


    Thanks for this great information. Is there a source you recommend for Cat's Claw or a supplement that combines several that you've mentioned above?

    Thanks again!

  • Benfield_john

    All the above is a wonderful concept, but for those of us who have RA at a fairly high level, these things don't stop the joint pain. You gotta have the drugs, such as Enbrel if you can afford it and metho………
    I can't improve much more on my diet of veggies and fruits every day so the drugs have to remain until someone is able to reverse RA………..mojo

  • Call Scott, who has a natural Pharmacy at 845 781 7613

  • Bella

    what do you think of Zyflamend by New Chapter?

  • Betsy

    Dr. Lipman,

    Thanks so much! Will do.

  • I think it is a good product

  • Cindi Saunders

    I recently stopped taking Vitamin E because of some studies that found negative results regarding this vitamin as a supplement for women. Can you comment on this?

  • Patricia Hernandez

    Hello Cindi:
    My name is Patricia, you can email me @: [email protected]

    I'm a Certified Health Specialist /Consultant, and want to share what I've learned that about the quality of Vitamin E's that many company's don't put in. If you're still out on cyber space email for more info. Thanks.


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  • Natural remedies for inflammation such as omega 3 fish oil that helps to boost the anti-inflammatory effect of it, you might want to consider lessening intake of wheat and dairy products which are common causes of inflammation and allergies.

  • Call Scott, who has a natural Pharmacy at 845 781 7613

  • California girl

    I read that sugar causes inflammation and our American diets are loaded with it, along with so many foods that incorporate some type of corn by-product in them. Try cutting out sugar (including breads, rice, pasta, etc.). And, consider following the blood type diet (Eating for your Blood type – which is basically avoiding certain foods). This has helped me immensely!

    I love this type of honest information (article above) and teaching us to heal from the inside out. This is the direction that medicine needs to go, but too many companies make money off of it, so unfortunately the cycle continues. The natural way is best. Thank you for the article!!!

  • j

    Learn to meditate! is a good site to learn from – a lot of free valuable tools.

  • I would a few powerful inflammation remedies to this list – Turmeric, ginger, boswelia, systemic enzymes and more. You can learn how to combine them all together here:

  • Thank you for adding your suggestions Meital.
    Turmeric is an all time favorite for me too.
    Katrine – Be Well Team

  • Anonymous

    Thank you for adding your suggestions Meital.
    Turmeric is an all time favorite for me too.
    Katrine – Be Well Team

  • Mark G

    Use only natural E not synthetic E, natural E won’t cause the problems your concerned about.

  • rattled

    My daughter has RA, diagnosed at 30. There is a way to put it into remission. We have done it! I know the medical community will scream, but in truth, it has happened! Go to: and read, read, read!! Then if you can, find a practicing MD or DO or Naturopath in your area who does the AP. If not, there is a doc in Iowa who studied with Dr. Brown, by the name of Sinnott who can help.

  • k9luv

    Except Monsanto bought them out!

  • Wendy

    I think I have fibromyalgia. Do you recommend Omega 3 and natural vit E along with changing my diet? And do you think it is mostly inflammation thats causing my joint pain? I am only 51 and i am hurting bad. Love the info!

  • carnell

    My daugther has lupus is vitamin d3 good for her.

  • Rachel

    John, try digestaqure. It is formulated to modulate your immune system so that it will stop attacking your joints. Wishing you the best of health.

  • Rachel

    Wendy, find a good integrative (functional) medicine doctor. You will get better results than going to a traditional medical doctor.

  • Natalia

    mojo i must say that you are not right with your believe about taking metotrexat is only way.Pleade take time and find on Google web side called Peters promise. REad about Peter.Thx iy

  • IDJazzman

    One thing to try and eliminate is your structural health of your body, especially the spine. When the spine is pinching nerves then the muscles fire and become very fatigued and achy. The medical field of doctors absolutely will not catch this. This may or may not be a contributing factor for you. My spouse starting having problems in her 40’s, finally became bad enough for her to see not one but two different specialized rheumatologists, which cost a lot of money. All the, bla, bla, bla, phony diagnosis’s, and in the end the old catch all, “you have fibromyalgia”, go home and suffer and here are some drugs. I had long suspected her spine having problems, but what do I know. She tried a number of different Chiropractic’s, none of them helped. I happened to learn of a method called manual therapy that is in the physical therapy field. Here is the catch, the person must be a certified manual therapist, which takes several years after they get their physical therapist degree. Not very many of them around. As suspected, the manual therapist explained that her spine and pelvis was a mess and getting worse. After two years of weekly visits he has been able to shift her spine and pelvis and a lot of the problems, like magic, of her so called fibromyalgia symptoms have disappeared. Along with these treatments we have focused in on nutrition to help feed her muscles. She feels like she is about 70 to 80 percent better than 2 years ago. This may or may not help you, but a thought for you to check out.